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This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age. Preface About og Editors Introduction: Progression of the Science of Ageing Chromatin Structure from Development to Ageing The Nuclear Envelope in Ageing and Progeria Mitochondrial DNA Mutations and Ageing The Proteasome and Ageing Gap Junctions and Ageing Cellular Senescence and Ageing Therapeutic Opportunities Presented by Modulation of Cellular Senescence Ageing at Molecular Level: Role of MicroRNAs CircRNA and Ageing Extracellular Vesicles and Cellular Ageing Fibrinogen, Coagulation, and Ageing An Insight into Platelets at Older Age: Cellular and Clinical Perspectives Ageing Skeletal Muscle: The Ubiquitous Muscle Stem Cell Age-Related Changes in Central Nervous System 5-Hydroxytryptamine Signalling and Its Potential Effects on the Regulation o... Systems Biology of Ageing