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This second eidtion explores new and updated techniques used to understand solid target-specific models in computational toxicology. Chapters are divided into four sections, detailing molecular descriptors, QSAR and read-across, molecular and data modeling techniques, computational toxicology in drug discovery, molecular fingerprints, AI techniques, and safe drug design. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Toxicology: Methods and Protocols, Second Editon aims to ensure successful results in the further study of this vital field. Dedication Preface Contributors The Tools of the Game QSAR: Using the Past to Study the Present Molecular Similarity in Predictive Toxicology with a Focus on the q-RASAR Technique Weight of Evidence: Criteria and Applications Integration of QSAR and NAM in the Read-Across Process for an Effective and Relevant Toxicological Assessment Molecular and Data Modeling Automated Workflows for Data Curation and Machine Learning to Develop Quantitative Structure-Activity Relationships Applicability Domain for Trustable Predictions Approaching Pharmacological Space: Events and Components The Potential of Molecular Docking for Predictive Toxicology Computational Toxicology Methods in Chemical Library Design and High-Throughput Screening Hit Validation Applicative Examples of Predictive Toxicology Toxicity Potential of Nutraceuticals Development, Use, and Validation of (Q)SARs for Predicting Genotoxicity and Carcinogenicity: Experiences from Ital... Adverse Outcome Pathways Mechanistically Describing Hepatotoxicity Machine Learning in Early Prediction of Metabolism of Drugs In Vitro Cell-Based MTT and Crystal Violet Assays for Drug Toxicity Screening Recent Advances in Nanodrug Delivery Systems Production, Efficacy, Safety, and Toxicity Investigating the Benefit-Risk Profile of Drugs: From Spontaneous Reporting Systems to Real-World Data for Pharmac... MolPredictX: A Pioneer Mobile App Version for Online Biological Activity Predictions by Machine Learning Models TIRESIA and TISBE: Explainable Artificial Intelligence Based Web Platforms for the Transparent Assessment of the D... PFAS-Biomolecule Interactions: Case Study Using Asclepios Nodes and Automated Workflows in KNIME for Drug Discover... Index