Acording to http://nintendo.wikia.com:

"Big Brain Academy: Wii Degree is a video game for the Wii. It is a sequel to the 6 million seller hit, Big Brain Academy for the Nintendo DS. It was announced on September 14, 2006, during Japan's Wii event. The game features new puzzles and mini-games that the player will be able to solve. The main characters of the games are the customizable Miis that you are able to make on the Wii console. The European name for the game is plainly Big Brain Academy for Wii"

Source: http://nintendo.wikia.com/wiki/Big_Brain_Academy:_Wii_Degree

TESTED

Format: WBFS

Note: to change to ISO format, the best way is to download and install "Wii Backup Manager"