Textbook in PDF format

The Hypothalamus is an important area of the brain for understanding a variety of neurological disorders. This volume summarizes for readers the anatomy and physiology of the middle and posterior hypothalamus, to better understand pathology and treatment of hypothalamus related disorders. In addition to anatomy and physiology in humans, cytoarchitecture and chemoarchitecture in rodents is provided. The volume explores the role of the hypothalamus in disorders of eating, sleeping, anxiety, and mood, as well as its role in sexual behavior and gender identity. Coverage includes how Parkinson’s, Alzheimer’s and other neurological disorders relate to the hypothalamus. Foreword Preface Contributors Introduction: The middle and posterior hypothalamus Supraoptic and paraventricular nucleus more than a neuroendocrine system Vasopressin and oxytocin beyond the pituitary in the human brain Central and peripheral release of oxytocin: Relevance of neuroendocrine and neurotransmitter actions for physiology and behavior Organization of the neuroendocrine and autonomic hypothalamic paraventricular nucleus Sex differences of oxytocin and vasopressin in social behaviors Oxytocin, eating behavior, and metabolism in humans The supraoptic and paraventricular nuclei in healthy aging and neurodegeneration Perinatal stress and epigenetics The hypothalamus in anxiety disorders Congenital isolated central hypothyroidism: Novel mutations and their functional implications Zona incerta The zona incerta system: Involvement in attention and movement Ventromedial nucleus and dorsomedial nucleus The role of the dorsomedial and ventromedial hypothalamus in regulating behaviorally coupled and resting autonomic drive The subfornical organ and organum vasculosum of the lamina terminalis: Critical roles in cardiovascular regulation and the control of fluid balance Lamina terminalis fenestration: An important neurosurgical corridor Arcuate nucleus, median eminence, and hypophysial pars tuberalis Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier The human hypothalamic kisspeptin system: Functional neuroanatomy and clinical perspectives Kisspeptin and neurokinin B expression in the human hypothalamus: Relation to reproduction and gender identity The infundibular peptidergic neurons and glia cells in overeating, obesity, and diabetes Hypothalamus and weight loss in amyotrophic lateral sclerosis Lateral tuberal nucleus Lateral hypothalamic area, perifornical area The orexin/hypocretin system in neuropsychiatric disorders: Relation to signs and symptoms Pleasure, addiction, and hypocretin (orexin) Tuberomamillary complex Histamine receptors, agonists, and antagonists in health and disease The tuberomamillary nucleus in neuropsychiatric disorders Subthalamic nucleus Imaging of the human subthalamic nucleus Neuropsychiatric effects of subthalamic deep brain stimulation The subthalamic nucleus and the placebo effect in Parkinson's disease Corpora mamillaria, fornix, and mamillothalamic tract Electrical stimulation of the fornix for the treatment of brain diseases The contribution of mamillary body damage to Wernicke's encephalopathy and Korsakoff's syndrome Index