Cast Cast overview, first billed only: Casey Kasem ... Shaggy (voice) Frank Welker ... Fred / Scooby-Doo (voice) Nicole Jaffe ... Velma (voice) Heather North ... Daphne (voice) (as Heather North Kenny) Jesse Borrego ... Luis Otero / Musician #2 / Suspicious Tourist (voice) Maria Canals-Barrera ... Sofia Otero / Old Woman #2 (voice) (as Maria Canals) Brandon Gonzalez ... Jorge Otero (voice) Castulo Guerra ... Señor Fuente / Man #1 (voice) Benito Martinez ... El Curandero / Man #2 (voice) Darlene Mendoza ... Natalia Otero / Little Girl (voice) Candi Milo ... Charlene Otero / Museum Guide / Old Woman #1 (voice) Rita Moreno ... Doña Dolores / Woman #3 (voice) Allyse Rivera ... Carolina Otero (voice) Casey Sandino ... Sebastian Otero / Little Boy (voice) Eddie Santiago ... Alejo Otero / Musician #1 (voice)